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FLASH GENE
Symbol LLGL1 contributors: mct/npt - updated : 10-03-2010
HGNC name lethal giant larvae homolog 1 (Drosophila)
HGNC id 6628
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • several conserved functional domains found in Lgl, suggesting that these proteins may have closely related functions (Shimanski 2005)
    • HOMOLOGY
    interspecies homolog to drosophila Lgl
    Homologene
    FAMILY
  • WD repeat L(2)GL family
    • CATEGORY structural protein , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • control of cell proliferation
  • its expression increased cell adhesion and decreased cell migration (Shimanski 2005)
  • binds Myosin II and is involved in maintaining cell polarity and epithelial integrity (Shimanski 2005)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of DLG1/SCRIB/LLGL1 tumour suppressor complex, interacting with tSNARE syntaxin 4 (Massimi 2008)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • non muscle myosin II heavy chain binding
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in Smith-Magenis syndrome
    constitutional somatic mutation      
    mutated by aberrant splicing exclusively in hepatocellular carcinoma (HCC), and involved in HCC progression (Lu 2009)
    tumoral     --low  
    involved in development and progression of colon cancer and malignant melanoma (Tsuruga 2007)
    tumoral     --low  
    loss of expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis (Tsuruga 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS