Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNG5 contributors: mct - updated : 08-12-2021
HGNC name guanine nucleotide binding protein (G protein), gamma 5
HGNC id 4408
Location 1p22.3      Physical location : 84.964.006 - 84.972.262
Synonym symbol(s) FLJ92393
EC.number 3.6.5.1/ 3.6.5.2/ 3.6.5.3
DNA
TYPE functioning gene
STRUCTURE 8.26 kb     4 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text with alternative transcriptional star sites resulting from two separate,closely linked 5' promoters (Liu)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 806 - 68 - 2020 33000557
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Lymphoid/Immunespleen   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated LipoP
mono polymer heteromer , trimer
HOMOLOGY
interspecies ortholog to murine Gng5
homolog to Xenopus Xl.7680
homolog to zebrafish Dr.9659
homolog to C.elegans K02A4.2
Homologene
FAMILY G protein gamma family
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • modulating or transducing various transmembrane signaling systems
  • required for the GTPase activity and for the replacement of GDP by GTP
  • PPP1R1A, OTULINL, ENO2, and GNG5 are potential regulators of islet function
  • likely a critical role of GNG5 in cortical development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component heterotrimeric G-protein GTPase, gamma-subunit
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GDP, GTP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gliomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is an independent prognostic indicator for glioma patients, as well as a promising subtype-associated biomarker in molecular classification of gliomas.
  • Therapy target
    ANIMAL & CELL MODELS