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FLASH GENE

Symbol

LY9

contributors: mct - updated : 16-02-2016

HGNC name	lymphocyte antigen 9
HGNC id	6730

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   LY9 and SLAMF6 expression is increased on the surface of SLE T cells compared with normal cells tumoral     --low   in hepatocellular carcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer hemopathy   could serve as a novel target for the treatment of B cell-related diseases

ANIMAL & CELL MODELS

Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies