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FLASH GENE
Symbol LY9 contributors: mct - updated : 16-02-2016
HGNC name lymphocyte antigen 9
HGNC id 6730
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
four immunoglobulin like domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to murine Ly-9
Homologene
FAMILY immunoglobulin superfamily
CATEGORY adhesion , antigen
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • putatively involved in adhesion reaction between T lymphocyte and accessory cells
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • plays a unique role as an inhibitory cell surface receptor regulating the size of the thymic innate CD8(+) T cell pool and the development of invariant NKT cells.
  • LY9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses
  • is a specific marker of normal hepatocytes and plays a potential role in the control of proliferation of HCC cells
  • plays a role during Hepatitis C virus (HCV) entry, likely by enhancing entry of viral particle within hepatocytes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • LY9/SLAMF6 signaling mediates increased nuclear abundance and recruitment of RORC to the proximal IL17A promoter, resulting in increased trans-activation and gene expression
    • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    LY9 and SLAMF6 expression is increased on the surface of SLE T cells compared with normal cells
    tumoral     --low  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    could serve as a novel target for the treatment of B cell-related diseases
    ANIMAL & CELL MODELS
  • Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies