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FLASH GENE
Symbol CDK10 contributors: mct - updated : 17-10-2017
HGNC name cyclin-dependent kinase (CDC2-like) 10
HGNC id 1770
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a PSTAIRE-like motif (PISSLRE)
HOMOLOGY
interspecies ortholog to yeast S.cerevisiae cdc28
intraspecies homolog to cyclin dependent kinase (CDC2-like) related protein kinase
Homologene
FAMILY
  • serine/threonine family of protein kinases
  • Cdc2 family of kinases
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine kinase
  • acting in G2 phase of the cell cycle
  • important determinant of resistance to endocrine therapy for breast cancer
  • critical function in neurogenesis by modulation of RAF1 expression
  • is a protein kinase that controls ETS2 degradation
    • CELLULAR PROCESS cell cycle, checkpoint
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CDK10/CCNQ is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RHOA signaling
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALKAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancers and correlates with disease progression and poor survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a prognostic biomarker for breast cancer
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    potential therapeutic target for biliary tract cancer cells
    ANIMAL & CELL MODELS
  • homozygous Cdk10-knockout mice died postnatally with severe growth retardation, skeletal defects, and kidney and lung abnormalities