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FLASH GENE

Symbol

CDK10

contributors: mct - updated : 17-10-2017

HGNC name	cyclin-dependent kinase (CDC2-like) 10
HGNC id	1770

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.75 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

several initiation sites

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D16S422 - D16S402 - D16S520 - COX4I1 - D16S413 - CDK10 - FANCA FANCA - MC1R - qter
Authors	GeneMap (98)

RNA

TRANSCRIPTS	type	messenger

text	several complex alternatively spliced isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052988 13 initiation site 1815 NP_443714 41 360 - 2001 11313931 NM_052987 13 splicing 1643 NP_443713 - 272 2001 11313931 NM_001160367 13 - 1777 NP_001153839 - 289 - 2001 11313931 NM_001098533 13 - 1759 NP_001092003 - 283 - 2001 11313931

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PSTAIRE-like motif (PISSLRE)

HOMOLOGY

interspecies

ortholog to yeast S.cerevisiae cdc28

intraspecies

homolog to cyclin dependent kinase (CDC2-like) related protein kinase

Homologene

FAMILY	serine/threonine family of protein kinases
	Cdc2 family of kinases

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	serine/threonine kinase
	acting in G2 phase of the cell cycle
	important determinant of resistance to endocrine therapy for breast cancer
	critical function in neurogenesis by modulation of RAF1 expression
	is a protein kinase that controls ETS2 degradation

CELLULAR PROCESS	cell cycle, checkpoint

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CDK10/CCNQ is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RHOA signaling

INTERACTION

DNA

RNA

small molecule

protein

is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ALKAS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancers and correlates with disease progression and poor survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a prognostic biomarker for breast cancer
Therapy target
	System Type Disorder Pubmed cancer digestive liver potential therapeutic target for biliary tract cancer cells

ANIMAL & CELL MODELS

homozygous Cdk10-knockout mice died postnatally with severe growth retardation, skeletal defects, and kidney and lung abnormalities