Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CDK10

contributors: mct - updated : 17-10-2017

HGNC name	cyclin-dependent kinase (CDC2-like) 10
HGNC id	1770

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ALKAS Al Kaissi syndrome
Location	16q24.3      Physical location : 89.753.075 - 89.762.771
Synonym symbol(s)	CDC2R1, PISSLRE, ALKAS,
EC.number	2.7.11.22

DNA

TYPE	functioning gene
STRUCTURE	9.75 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

text structure

several initiation sites

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D16S422 - D16S402 - D16S520 - COX4I1 - D16S413 - CDK10 - FANCA FANCA - MC1R - qter
Authors	GeneMap (98)

RNA

TRANSCRIPTS	type	messenger

text	several complex alternatively spliced isoforms

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_052988 13 initiation site 1815 NP_443714 41 360 - 2001 11313931 NM_052987 13 splicing 1643 NP_443713 - 272 2001 11313931 NM_001160367 13 - 1777 NP_001153839 - 289 - 2001 11313931 NM_001098533 13 - 1759 NP_001092003 - 283 - 2001 11313931

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

cell cycle

cell cycle

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a PSTAIRE-like motif (PISSLRE)

HOMOLOGY

interspecies

ortholog to yeast S.cerevisiae cdc28

intraspecies

homolog to cyclin dependent kinase (CDC2-like) related protein kinase

Homologene

FAMILY	serine/threonine family of protein kinases
	Cdc2 family of kinases

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	serine/threonine kinase
	acting in G2 phase of the cell cycle
	important determinant of resistance to endocrine therapy for breast cancer
	critical function in neurogenesis by modulation of RAF1 expression
	is a protein kinase that controls ETS2 degradation

CELLULAR PROCESS	cell cycle, checkpoint

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

CDK10/CCNQ is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RHOA signaling

INTERACTION

DNA

RNA

small molecule

protein

is a protein kinase that partners with CCNQ to phosphorylate substrates such as ETS2 and PKN2 in order to modulate cellular growth

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ALKAS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancers and correlates with disease progression and poor survival

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may serve as a prognostic biomarker for breast cancer
Therapy target
	System Type Disorder Pubmed cancer digestive liver potential therapeutic target for biliary tract cancer cells

ANIMAL & CELL MODELS

homozygous Cdk10-knockout mice died postnatally with severe growth retardation, skeletal defects, and kidney and lung abnormalities