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FLASH GENE
Symbol FZD2 contributors: mct - updated : 12-02-2018
HGNC name frizzled homolog 2 (Drosophila)
HGNC id 4040
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal cysteine-rich domain that binds Wnt ligands and thus primes the Wnt signal pathway
  • seven transmembrane segments (7TM)
  • a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity gene
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • Frizzled family of Wnt receptors
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • exhibiting characteristics of a WNT receptor
  • activating Dishevelled
  • involved in signal transduction
  • FZD2 and FZD7 are competent to signal via the canonical pathway
  • extracellular N-terminal of the Fzd2 receptor has a cysteine-rich domain (CRD) that binds Wnt ligands and thus primes the Wnt signal pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • WNT5a/FZD2 signaling pathway contributed to increasing intracellular CaČ&
    • 8314; in nerve cells under physiological and pathological conditions
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ROR2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with FZD2
  • genetic interactions between FZD2, FZD7 and VANGL2, DVL3 and WNT genes reflect interactions among different signaling pathways in developmental processes that are highly sensitive to perturbations in Frizzled signaling
  • HMGA2 directly regulates GATA6 and thereby modulates FZD2 expression
  • is implicated in the Wnt/PCP pathway, and is required for the WNT5A-mediated recruitment of DVL2 to the membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) RBNS4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be a potential marker for endometrial cancer (EC) metastasis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    target for future therapies for endometrial cancer (EC)
    ANIMAL & CELL MODELS
  • Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice