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FLASH GENE

Symbol

FZD2

contributors: mct - updated : 12-02-2018

HGNC name	frizzled homolog 2 (Drosophila)
HGNC id	4040

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	3.82 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001466 1 - 3834 NP_001457 - 565 - 1998 9813155

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive female system ovary       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	brain, lung, kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal cysteine-rich domain that binds Wnt ligands and thus primes the Wnt signal pathway
	seven transmembrane segments (7TM)
	a C terminal hydrophilic segment, comprising the S/T-X-X-X-W motif

HOMOLOGY

interspecies

homolog to Drosophila frizzled polarity gene

Homologene

FAMILY	G protein coupled receptor superfamily
	Frizzled family of Wnt receptors

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	exhibiting characteristics of a WNT receptor
	activating Dishevelled
	involved in signal transduction
	FZD2 and FZD7 are competent to signal via the canonical pathway
	extracellular N-terminal of the Fzd2 receptor has a cysteine-rich domain (CRD) that binds Wnt ligands and thus primes the Wnt signal pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

	WNT5a/FZD2 signaling pathway contributed to increasing intracellular Ca²&
	8314; in nerve cells under physiological and pathological conditions

a component

INTERACTION

DNA

RNA

small molecule

protein	ROR2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with FZD2
	genetic interactions between FZD2, FZD7 and VANGL2, DVL3 and WNT genes reflect interactions among different signaling pathways in developmental processes that are highly sensitive to perturbations in Frizzled signaling
	HMGA2 directly regulates GATA6 and thereby modulates FZD2 expression
	is implicated in the Wnt/PCP pathway, and is required for the WNT5A-mediated recruitment of DVL2 to the membrane

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

RBNS4

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be a potential marker for endometrial cancer (EC) metastasis
Therapy target
	System Type Disorder Pubmed cancer reproductive uterus target for future therapies for endometrial cancer (EC)

ANIMAL & CELL MODELS

Fzd2 is changed in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice