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FLASH GENE
Symbol RNH1 contributors: - updated : 13-12-2006
HGNC name ribonuclease/angiogenin inhibitor 1
HGNC id 10074
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 intestinelarge intestinecolon moderately
 liver   moderately
 pancreas exocrine   moderately
Lymphoid/Immunelymph node   moderately
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
 female systemplacenta  highly
 female systemovary  moderately
 male systemtestis  moderately
 male systemprostate  moderately
Skin/Tegumentskin   highly
Urinarykidney   moderately
Visualeye   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • fifteen LRR (leucine-rich) repeats
    • HOMOLOGY
    interspecies ortholog to murine Rnh1
    ortholog to rattus Rnh1
    ortholog to chimpanzee rnh
    Homologene
    FAMILY
  • family of proteinaceous cytoplasmic RNase inhibitors
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as an inhibitor of pancreatic RNase and angiogenin
  • may also function in the modulation of cellular activities
  • may be essential for control of mRNA turnover
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • RNA catabolism
    • a component
  • forming a tight one-to-one complex with the RNase
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS