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FLASH GENE
Symbol SOX15 contributors: mct/ - updated : 20-10-2012
HGNC name SRY (sex determining region Y)-box 15
HGNC id 11196
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain, G subfamily
  • a transactivation domain in the carboxyl terminus (transcription activation)
    • HOMOLOGY
    interspecies homolog to murine Sox15
    homolog to C.elegans k08a8.2
    Homologene
    FAMILY
  • group G of the Sry-related high-mobility-group (HMG) box genes family of transcritpion factors
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • involved in the regulation of embryonic development and in the determination of the cell fate
  • SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
  • involved in placental development and muscle regeneration
  • may have been involved in placental evolution
  • both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
  • crucial role in skeletal muscle regeneration
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text male gonad development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the 5'-AACAAT-3' sequence
    RNA
    small molecule
    protein
  • directs FOXK1 expression to the myogenic progenitor cell population, as it binds to an evolutionarily conserved site and recruits FHL3 to transcriptionally coactivate FOXK1 gene expression
  • activate NR5A1 gene expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    loss of SOX15 implicated in colon carcinoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Sox15 mutant mice display perturbed skeletal muscle regeneration, due in part to decreased numbers of satellite cells and decreased Foxk1 expression