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FLASH GENE

Symbol

SOX15

contributors: mct/ - updated : 20-10-2012

HGNC name	SRY (sex determining region Y)-box 15
HGNC id	11196

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system placenta       Homo sapiens   male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic progenitor cell Homo sapiens

cell lineage	progenitor of mesodermal lineage (MPCs)
cell lines
fluid/secretion

at STAGE

physiological period

fetal

Text	spinal cord highly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an high mobility group (HMG) domain, G subfamily
	a transactivation domain in the carboxyl terminus (transcription activation)

HOMOLOGY

interspecies	homolog to murine Sox15
	homolog to C.elegans k08a8.2

Homologene

FAMILY

group G of the Sry-related high-mobility-group (HMG) box genes family of transcritpion factors

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	modulator of LINE retroposons promoter activity
	involved in the regulation of embryonic development and in the determination of the cell fate
	SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
	involved in placental development and muscle regeneration
	may have been involved in placental evolution
	both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
	crucial role in skeletal muscle regeneration

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

text	male gonad development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the 5'-AACAAT-3' sequence

RNA

small molecule

protein	directs FOXK1 expression to the myogenic progenitor cell population, as it binds to an evolutionarily conserved site and recruits FHL3 to transcriptionally coactivate FOXK1 gene expression
	activate NR5A1 gene expression

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   loss of SOX15 implicated in colon carcinoma (

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Sox15 mutant mice display perturbed skeletal muscle regeneration, due in part to decreased numbers of satellite cells and decreased Foxk1 expression