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FLASH GENE
Symbol SOX15 contributors: mct/ - updated : 20-10-2012
HGNC name SRY (sex determining region Y)-box 15
HGNC id 11196
Location 17p13.1      Physical location : 7.491.497 - 7.493.488
Synonym name protein SOX-15
Synonym symbol(s) SOX20, SOX26, SOX27, SOXF
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1394 - 233 - 2007 17363903
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systemplacenta    Homo sapiens
 male systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
cell lineage progenitor of mesodermal lineage (MPCs)
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text spinal cord highly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an high mobility group (HMG) domain, G subfamily
  • a transactivation domain in the carboxyl terminus (transcription activation)
  • HOMOLOGY
    interspecies homolog to murine Sox15
    homolog to C.elegans k08a8.2
    Homologene
    FAMILY
  • group G of the Sry-related high-mobility-group (HMG) box genes family of transcritpion factors
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • modulator of LINE retroposons promoter activity
  • involved in the regulation of embryonic development and in the determination of the cell fate
  • SOX15, FHL3 and FOXK1 function to coordinately regulate the myogenic progenitor cell population and skeletal muscle regeneration
  • involved in placental development and muscle regeneration
  • may have been involved in placental evolution
  • both SOX7 and SOX15 are able to induce the early stages of myogenesis, but only SOX7 is sufficient to initiate the formation of fully differentiated skeletal myocytes
  • crucial role in skeletal muscle regeneration
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text male gonad development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the 5'-AACAAT-3' sequence
    RNA
    small molecule
    protein
  • directs FOXK1 expression to the myogenic progenitor cell population, as it binds to an evolutionarily conserved site and recruits FHL3 to transcriptionally coactivate FOXK1 gene expression
  • activate NR5A1 gene expression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    loss of SOX15 implicated in colon carcinoma (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Sox15 mutant mice display perturbed skeletal muscle regeneration, due in part to decreased numbers of satellite cells and decreased Foxk1 expression