Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PTPRO

contributors: mct - updated : 01-10-2013

HGNC name	protein tyrosine phosphatase, receptor type, O
HGNC id	9678

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NPHS6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in primary lung cancer by hypermethylation

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	PTPRO promoter hypermethylation as a potential biomarker in esophageal squamous cell carcinoma (ESCC)
	PTPRO expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy (IgAN), and may be predictive of clinical and pathological severity
Therapy target

ANIMAL & CELL MODELS

in Ptpro mutant mice, subsets of trigeminal ganglion neurons grow longer and more elaborate axonal branches