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FLASH GENE
Symbol PTPRO contributors: mct - updated : 01-10-2013
HGNC name protein tyrosine phosphatase, receptor type, O
HGNC id 9678
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a single catalytic domain in its cytoplasmic region
  • multiple fibronectin type III-like domains in its extracellular region
  • a hydrophobic transmembrane (TM)
  • a single intracellular tyrosine phosphatase domain
    • HOMOLOGY
    intraspecies homolog to PTPU2-LSB from glomerular epithelial podocyte membrane protein
    Homologene
    FAMILY PTPR family
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text Type I membrane protein
    basic FUNCTION
  • involved in cellular differentiation processes
  • may be involved in axon guidance both as a ligand and as a neuronal receptor
  • implicated in the guidance of motor and retinal axons
  • required for peptidergic differentiation and process outgrowth of sensory neurons, as well as mature sensory function
  • implicated in axon growth and guidance during embryonic development
  • is a potential target gene of Wnt/CTNNB1 signaling and may function as a novel receptor for WNT
  • role of PTPRO in learning and memory
  • is a novel regulator of mammary epithelial transformation, a potential tumor suppressor, and a predictive biomarker for breast cancer
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of TCL1A in PTPROt suppression, important in the pathogenesis ofchronic lymphocytic leukemia (CLL)
  • ERBB2/HER2 is a direct substrate of PTPRO and loss of PTPRO increased ERBB2-induced cell proliferation and transformation, together with tyrosine phosphorylation of ERBB2
    • cell & other
    REGULATION
    induced by Wnt/CTNNB1 signaling in a T cell factor/lymphoid enhancer factor dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHS6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary lung cancer by hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PTPRO promoter hypermethylation as a potential biomarker in esophageal squamous cell carcinoma (ESCC)
  • PTPRO expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy (IgAN), and may be predictive of clinical and pathological severity
    • Therapy target
    ANIMAL & CELL MODELS
  • in Ptpro mutant mice, subsets of trigeminal ganglion neurons grow longer and more elaborate axonal branches