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FLASH GENE
Symbol PTPRO contributors: mct - updated : 01-10-2013
HGNC name protein tyrosine phosphatase, receptor type, O
HGNC id 9678
DNA
TYPE functioning gene
STRUCTURE 276.07 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
text six variants, four isoforms
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 6379 - 1216 renal glomerulus,brain 1995 7665166
26 - 6295 200 1188 renal glomerulus,brain 1995 7665166
14 - 5002 - 405 B-lymhpoid organs 1995 7665166
13 - 4918 - 377 B-lymphoid organs, macrophages 2011 22001392
  • truncated isoform
  • down-regulated in chronic lymphocytic leukemia (CLL)
    • 14 - 3986 - 377 B-lymphoid organs 1995 7665166
    15 - 3970 - 405 B-lymphoid organs 1995 7665166
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain     Mus musculusFetal
     gangliasensory gangliadorsal root   Mus musculusAdult
    Olfactory (smell)olfactory bulb   highly Mus musculusAdult
    Respiratorylung    
    Urinarykidneynephronrenal capsuleglomerulus  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinarypodocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		a single catalytic domain in its cytoplasmic region
  • multiple fibronectin type III-like domains in its extracellular region
  • a hydrophobic transmembrane (TM)
  • a single intracellular tyrosine phosphatase domain
    • HOMOLOGY
    intraspecies homolog to PTPU2-LSB from glomerular epithelial podocyte membrane protein
    Homologene
    FAMILY PTPR family
    CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text Type I membrane protein
    basic FUNCTION
  • involved in cellular differentiation processes
  • may be involved in axon guidance both as a ligand and as a neuronal receptor
  • implicated in the guidance of motor and retinal axons
  • required for peptidergic differentiation and process outgrowth of sensory neurons, as well as mature sensory function
  • implicated in axon growth and guidance during embryonic development
  • is a potential target gene of Wnt/CTNNB1 signaling and may function as a novel receptor for WNT
  • role of PTPRO in learning and memory
  • is a novel regulator of mammary epithelial transformation, a potential tumor suppressor, and a predictive biomarker for breast cancer
    • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role of TCL1A in PTPROt suppression, important in the pathogenesis ofchronic lymphocytic leukemia (CLL)
  • ERBB2/HER2 is a direct substrate of PTPRO and loss of PTPRO increased ERBB2-induced cell proliferation and transformation, together with tyrosine phosphorylation of ERBB2
    • cell & other
    REGULATION
    induced by Wnt/CTNNB1 signaling in a T cell factor/lymphoid enhancer factor dependent manner
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHS6
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in primary lung cancer by hypermethylation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • PTPRO promoter hypermethylation as a potential biomarker in esophageal squamous cell carcinoma (ESCC)
  • PTPRO expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy (IgAN), and may be predictive of clinical and pathological severity
    • Therapy target
    ANIMAL & CELL MODELS
  • in Ptpro mutant mice, subsets of trigeminal ganglion neurons grow longer and more elaborate axonal branches