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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

AHNAK

contributors: mct - updated : 28-06-2020

HGNC name	AHNAK nucleoprotein
HGNC id	347

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function resulted in a reduced calcium influx upon TCR crosslinking and subsequent poor activation of the transcription factor NFAT tumoral     --over   highly expressed and plays a key role in cell migration and invasion in mesothelioma tumoral     --over   of ANHAK and TMEFF1 in ovarian cancer indicated a higher degree of tumor malignancy and a worse prognosis

Susceptibility

Variant & Polymorphism

Candidate gene	autoantigen in systemic lupus erythematosus(SLE)
Marker	has the potential to be a new marker for detecting mesothelioma
Therapy target
	System Type Disorder Pubmed immunology infectious   potential target for therapeutic intervention cancer reproductive ovary the interaction between AHNAK and TMEFF1 may become a potential anti-tumor target for ovarian cancer treatment

ANIMAL & CELL MODELS

	Ahnak-deficient mice were protected from high-fat diet-induced obesity
	Ahnak deficiency plays a positive role for hippocampal neurogenesis in adult mice because proliferating cells were increased in Ahnak(-/-) mice and advanced to mature neurons