| SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| intracellular,nucleus,nucleoplasm
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| text
| membrane accumulation of MARK2 induced by DVL1L1 is regulated by its phosphorylation status, which is important for MARK2 to regulate the microtubule dynamics  |
| basic FUNCTION
| potentially involved in the control of cell polarity |
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involved in microtubule stability and cancer |
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adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway |
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phosphorylates tau protein at sites that cause detachment from microtubules in Alzheimer neurofibrillary degeneration |
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conserved kinase that plays crucial roles in cell polarity |
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specifically regulates development of dendrites in hippocampal neurons |
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with MARK3, phosphorylate class IIa HDACs on one of their multiple 14-3-3 binding sites and alter their subcellular localization and repressive function |
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negatively regulates dendrite development through phosphorylation of MAP2 |
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MARK1, MARK2, MARK3, MARK4 phosphorylate MAPT in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments |
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regulates axon formation via phosphorylation of a kinesin superfamily protein KIF13B |
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potentially a positive regulator for lipogenesis in adipocytes and hepatocytes |
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plays key roles in the development of cell polarity |
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may contribute to cell polarization by regulating the turnover of ARHGEF2 at microtubules |
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appears to regulate cell polarization via several microtubule-associating proteins, such as KIF13B and ARHGEF2 |
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is thought to regulate microtubule dynamics by inhibiting microtubule binding of microtubule-associated proteins |
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potential novel function in the maintenance of mature dendritic spine morphology by regulating microtubule growth and the accumulation of SRCIN1 in dendritic spines |
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ROCK1/MARK2-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland |
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MARK1, MARK2, MARK3, MARK4 are implicated in phosphorylation of tau protein, causing formation of neurofibrillary tangles in Alzheimer disease (AD) |
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has a substantial role in regulation of vital cellular processes like induction of polarity, regulation of cell junctions, cytoskeleton structure and cell differentiation |
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role for MARK2 in maintaining the spindle at the cell's geometric center |
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role in correcting mitotic spindle off-centring induced by actin disassembly |
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MARK2 and MARK4 regulate Sertoli cell blood-testis barrier (BTB) Dynamics through microtubule and actin cytoskeletons |
