| basic FUNCTION
| stimulating growth of the cells in an autocrine manner |
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mediating hormonal action on the growth of cancer cells |
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FGF4 and FGF8 are the principal FGFs required for both axis extension and limb bud outgrowth |
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expression in prostate cancer cells increases their growth as intratibial tumors and modulates formation of bone lesions  |
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FGF8, FGF17 and EMX2 play distinct roles in the molecular regionalization of frontal cortex subdivisions ( |
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involved in gastrulation, regionalization of the brain, axial elongation and organogenesis of the limb and face |
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may participate in the degradation of cartilage and exacerbation of osteoarthritis |
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regulates myoblast differentiation through the regulation of MYOD1 expression |
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may have a physiological role in bone acting in an autocrine/paracrine manner |
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crucial role of a defined FGF8 expression pattern controlling inner ear formation in vertebrates |
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regulating the development of the thalamic motor learning area |
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FGF8 signalling is both required and sufficient to induce rostral Cajal-Retzius cells |
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in addition to its organizer function, plays a crucial role in maintaining the lineage boundary at the midbrain-hindbrain by restricting cell movement |
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GBX2 and FGF8 are sequentially required for formation of the midbrain-hindbrain compartment boundary |
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FGF4 and FGF8 action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM (presomitic mesoderm) progenitor tissue |
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FGF4 and FGF8 signaling acts as the sole mediator of wavefront activity |
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chemotactic and chemokinetic for cardiac neural crest |
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with FGF17, is a key factor in the patterning of the mid-hindbrain region with a complex picture of spatiotemporal gene expression during the various stages of cerebellar development |
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HTRA1 and FGF8 may function coordinately in the common FGF signaling pathway |
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FGF8 and FGF10 promotes the proliferation of the cardiac progenitor cells that form the arterial pole of the heart |
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FGF8 signaling is involved in craniofacial development |
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FGF8 receiving cells control likely both, the propagation width and the signal strength of the morphogen |
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FGF8 acts as a binary switch that distinguishes tubular elongation from lumen formation in kidney |
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regulates postnatal development of paraventricular nucleus neuroendocrine cells |
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FGF8 and FGFR3 may play an important role in the onset of deep zone necrosis and pathogenesis in osteochondropathy Kashin-Beck disease in adolescent children |
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FGF8 and SHH promote the survival and maintenance of multipotent neural crest progenitors |
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FGF8, FGF17 and FGF18 are required for closure of the embryonic ventral body wall |
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key regulator of limb development and several limb enhancer elements, and key signaling factor for embryo patterning |
