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FLASH GENE
Symbol SYT3 contributors: mct - updated : 26-11-2011
HGNC name synaptotagmin III
HGNC id 11511
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an intravesicular N terminal domain
  • a single transmembrane (TM) region,two protein kinase C-homologous repeats (Ca2+ binding domains C2)
  • two rigid Ca(2+)-binding domains undergoing large relative motions in solution, involved in interaction with SNARE complex
  • a conserved WHXL motif in the C terminus
    • mono polymer homomer , heteromer
    HOMOLOGY
    interspecies ortholog to murine Syt3
    ortholog to rattus Syt3
    Homologene
    FAMILY synaptotagmin family
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,granule
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,nucleus
    text
  • little or no SYT3 is present near the plasma membrane but that it is mainly localized in multivesicular bodies, which also contained much of the CXCR4
    • basic FUNCTION
  • calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
  • regulate vesicle trafficking and fusion of vesicles with membranes - processes that have been implicated in cell migration
  • multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS nervous system , exocytosis transport , endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • phosphorylation by WNK1 can regulate Ca2+ sensing and the subsequent Ca2+-dependent interactions mediated by SYT C2 domains
  • interaction with CXCR4 (essential for CXCR4 recycling in T cells and thereby for the maintenance of high CXCR4 surface levels required for migration)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS