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FLASH GENE

Symbol

SYT3

contributors: mct - updated : 26-11-2011

HGNC name	synaptotagmin III
HGNC id	11511

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	17.86 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001160329 11 - 2493 - 590 - - NM_001160328 11 - 2857 - 590 - - NM_032298 9 - 2928 - 590 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon amygdala

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an intravesicular N terminal domain
	a single transmembrane (TM) region,two protein kinase C-homologous repeats (Ca2+ binding domains C2)
	two rigid Ca(2+)-binding domains undergoing large relative motions in solution, involved in interaction with SNARE complex
	a conserved WHXL motif in the C terminus

mono polymer

homomer , heteromer

HOMOLOGY

interspecies	ortholog to murine Syt3
	ortholog to rattus Syt3

Homologene

FAMILY

synaptotagmin family

CATEGORY

structural protein , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus
text	little or no SYT3 is present near the plasma membrane but that it is mainly localized in multivesicular bodies, which also contained much of the CXCR4

basic FUNCTION	calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
	regulate vesicle trafficking and fusion of vesicles with membranes - processes that have been implicated in cell migration
	multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules
	SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

nervous system , exocytosis transport , endocytosis transport

PATHWAY

metabolism

signaling

a component

SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	phosphorylation by WNK1 can regulate Ca2+ sensing and the subsequent Ca2+-dependent interactions mediated by SYT C2 domains
	interaction with CXCR4 (essential for CXCR4 recycling in T cells and thereby for the maintenance of high CXCR4 surface levels required for migration)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS