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FLASH GENE

Symbol

SYT2

contributors: mct - updated : 07-10-2017

HGNC name	synaptotagmin II
HGNC id	11510

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_177402 9 - 7504 NP_796376 - 419 - 2001 11543631 NM_001136504 9 - 7514 NP_001129976 - 419 - 2001 11543631

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea     Homo sapiens Nervous brain limbic system hippocampus     Mus musculus   brain hindbrain cerebellum     Mus musculus Visual eye retina       Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains	an intravesicular N terminal domain
	a single transmembrane (TM) region
	a phospholipid binding C2C domain specifically binds a site adjacent to the CRIB/GBD of PAK1
	a C2B domain essential for neurotransmitter release at the NMJ
	two protein kinase C-homologous repeats (Ca2+ binding domains C2)
	a conserved WHXL motif in the C terminus

mono polymer

homomer , heteromer , complex

HOMOLOGY

interspecies	homolog to murine Syt2
	ortholog to rattus Syt2

Homologene

FAMILY

synaptotagmin family

CATEGORY

structural protein , transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,cytoplasm,cytosolic,vesicle
	intracellular,nucleus
text	in synaptic vesicles

basic FUNCTION	calcium sensor for transmitter release at the central synapse, involved in exocytosis and endocytosis
	functioning as a Ca2+ sensor for fast neurotransmitter release in caudal brain regions
	major isoform of the synaptotagmin family at mammalian neuromuscular junctions (NMJs), functioning as a calcium sensor for neurotransmission
	being an essential synaptotagmin isoform that functions in concert with other synaptotagmins in the Ca2+ triggering of neurotransmitter release
	unlike neurons, the lack of SYT2 in mast cells was not associated with increased spontaneous exocytosis
	controls regulated exocytosis but not other secretory responses of mast cells
	negative regulator of chemotaxis
	increases the dynamic range of synapses by driving release with a high Ca²+ cooperativity, as well as by suppressing a remaining, near-linear Ca²+ sensor
	synaptic vesicle protein, major isoform of the synaptotagmin family at mammalian neuromuscular junctions (NMJs) and functioning as a calcium sensor for neurotransmission
	regulates neurotransmitter release at human peripheral motor nerve terminals
	SYT1 and SYT2 can redundantly control transmitter release at specific brain synapses

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

nervous system , exocytosis transport , endocytosis transport

PATHWAY

metabolism

signaling

a component

multifunctional intrinsic membrane protein of synaptic vesicles of neurons and chromaffin granules

INTERACTION

DNA

RNA

small molecule	metal binding,
	calcium Ca2+

protein	phosphorylation by WNK1 can regulate Ca2+ sensing and the subsequent Ca2+-dependent interactions mediated by SYT C2 domains
	interacts with phospholipid membrane domains via SYT2, where it may cooperate in the SYT2-dependent endocytosis of activated FGFR1 by modulating cortical actin stability
	is an essential endocytic adapter for FGFR1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PMSN

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS