Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LGALS7 contributors: mct - updated : 25-05-2011
HGNC name lectin, galactoside-binding, soluble, 7 (galectin 7)
HGNC id 6568
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • galaptin (s-lectin) family
  • family of beta-galactoside-binding lectins
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • a fraction of LGALS7 is constitutively localized at mitochondria in a BCL2-dependent manner and sensitizes the mitochondria to the apoptotic signal
    • basic FUNCTION
  • involved in cell-cell and / or cell-matrix interactions necessary for normal growth control
  • arterial intima-enriched (AIE) gene, with periplakin, SPRR3, envoplakin, galectin 7, and plakoglobin that are functionally related in that they contribute to the stress properties of stratified epithelium
  • exhibit a pro-apoptotic function, as a new mitochondrial BCL2 interacting partner
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of LGALS7 to BCL2 may constitute a new target for enhancing the intrinsic apoptosis pathway
    • cell & other
    REGULATION
    Other regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS