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FLASH GENE
Symbol LGALS7 contributors: mct - updated : 25-05-2011
HGNC name lectin, galactoside-binding, soluble, 7 (galectin 7)
HGNC id 6568
Location 19q13.2      Physical location : 39.261.607 - 39.264.157
Synonym symbol(s) HKL14, LEG7, GAL7, PIG1
DNA
TYPE functioning gene
STRUCTURE 2.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivemale systemprostate   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
mono polymer monomer
HOMOLOGY
Homologene
FAMILY
  • galaptin (s-lectin) family
  • family of beta-galactoside-binding lectins
    • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • a fraction of LGALS7 is constitutively localized at mitochondria in a BCL2-dependent manner and sensitizes the mitochondria to the apoptotic signal
    • basic FUNCTION
  • involved in cell-cell and / or cell-matrix interactions necessary for normal growth control
  • arterial intima-enriched (AIE) gene, with periplakin, SPRR3, envoplakin, galectin 7, and plakoglobin that are functionally related in that they contribute to the stress properties of stratified epithelium
  • exhibit a pro-apoptotic function, as a new mitochondrial BCL2 interacting partner
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding of LGALS7 to BCL2 may constitute a new target for enhancing the intrinsic apoptosis pathway
    • cell & other
    REGULATION
    Other regulated by prolonged cyclic stress in vascular smooth muscle cells, which may have important implications to vascular disease
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS