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FLASH GENE

Symbol

TLE3

contributors: npt/SGE - updated : 27-07-2010

HGNC name	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
HGNC id	11839

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q23      Physical location : 70.340.542 - 70.390.256
Synonym name	enhancer of split groucho 3
	enhancer of split groucho-like protein 3
	transducin-like enhancer protein 3
Synonym symbol(s)	ESG3, ESG, KIAA1547, HsT18976, GRG3, FLJ39460

DNA

TYPE	functioning gene
STRUCTURE	46.00 kb     20 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001105192 20 - 5345 NP_001098662 - 769 - Miyasaka (1993) NM_020908 20 - 5318 NP_065959 - 760 - Miyasaka (1993) NM_005078 20 - 5354 NP_005069 - 772 - Miyasaka (1993)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain         Reproductive female system placenta       Respiratory lung           respiratory tract larynx       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	casein kinase II site/nuclear localization sequence motif
	a pleckstrin homology (PH) domain
	seven WD repeats (Trp-Asp domains)

conjugated

PhosphoP

mono polymer

homomer , heteromer , oligo

HOMOLOGY

interspecies	homolog to Drosophila split Groucho (Notch signaling pathway)
	homolog to murine Tle3 (98.8pc)
	homolog to rattus Tle3 (99.2pc)

Homologene

FAMILY

WD repeat Groucho/TLE family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	transcriptional corepressor binding to a number of transcription factors
	inhibiting the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
	might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (Carvalho 2010)

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	coexpressed with NOTCH implicating these molecules in the maintenance of the undifferentiated state in epithelial cells
	interacting with AES and TCF4 to influencing pituitary growth and development
	binding LEF1, TCF7, TCF7L1 and TCF7L2, FOXA2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         up-regulated (6- to 17-fold) in prostate tumors (Nakaya 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS