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FLASH GENE

Symbol

SERPINB5

contributors: mct/pgu - updated : 30-04-2010

HGNC name	serpin peptidase inhibitor, clade B (ovalbumin), member 5
HGNC id	8949

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     frequently in advanced cancer with metastases tumoral     --over   in high-grade prostate intraepithelial neoplasia (HGPIN) tumoral     --low   by hypermethylation in papillary thyroid carcinomas tumoral     --over   in lung cancer (squamous cell carcinomas) and in preneoplastic bronchial lesions tumoral     --over   by hypomethylation in a large fraction of pancreatic cancer cell lines and primary pancreatic carcinomas

Susceptibility

Variant & Polymorphism

Candidate gene	increased expression of SERPINB5 is associated with metastasis of hepatocellular carcinoma
	detection of SERPINB5 in blood may indicate aggressive disease in breast cancer
Marker	may be a useful marker to identify the potential for progression in oral squamous cell carcinoma
	cytoplasmic mSERPINB5 may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for adenocarcinoma patients whereas nuclear localization may be linked to promotion of angiogenesis
Therapy target

ANIMAL & CELL MODELS