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FLASH GENE
Symbol SERPINB4 contributors: mct - updated : 28-03-2011
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 4
HGNC id 10570
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
high molecular weight
HOMOLOGY
interspecies homolog to murine Scca2
Homologene
FAMILY
  • serpin family
  • OV serpin subfamily
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine proteinase inhibitor of cathepsin G and most cell kinase
  • may act as a protease inhibitor to modulate the host immune response against tumor cells
  • may be involved in the malignant behavior of squamous cell carcinoma cells
  • with SERPINB3, stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
  • with SERPINB3, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • carbonyl reductase may collaborate with SERPINB3 and SERPINB4 to mediate cancer behavior such as invasion or metastasis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung and prostate tumors
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS