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FLASH GENE

Symbol

SERPINB3

contributors: mct - updated : 28-03-2011

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
HGNC id	10569

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in T-lymphocyte peripheral to tongue squamous cell carcinoma tumoral     --low   in oral squamous cell carcinomas

Susceptibility

to progressive liver fibrosis

Variant & Polymorphism other	a novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala) associated with progressive liver fibrosis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS