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FLASH GENE
Symbol SERPINB3 contributors: mct - updated : 28-03-2011
HGNC name serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3
HGNC id 10569
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
high molecular weight
HOMOLOGY
interspecies homolog to C.elegans Srp2
Homologene
FAMILY serpin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm
basic FUNCTION
  • serine proteinase inhibitor of cathepsin S, K and L
  • may act as a protease inhibitor to modulate the host immune response against tumor cells
  • may be involved in the malignant behavior of squamous cell carcinoma cells
  • with SERPINB3, stimulates matrix metalloproteinase-9 production in cervical squamous cell carcinoma cell lines
  • important role of SERPINB3 in the modulation of programmed cell death by different mechanisms, both in inflammatory processes and in cancer
  • SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells
  • its anti-protease activity might be implicated in TGF-beta1 induction
  • with SERPINB4, are tumor-associated proteins that can inhibit papain-like cysteine proteases, including cathepsins L, K, and S
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein carbonyl reductase may collaborate with SERPINB3 and SERPINB4 to mediate cancer behavior such as invasion or metastasis
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in T-lymphocyte peripheral to tongue squamous cell carcinoma
    tumoral     --low  
    in oral squamous cell carcinomas
    Susceptibility to progressive liver fibrosis
    Variant & Polymorphism other a novel SCCA-1 variant (SCCA-PD), presenting a single mutation in the reactive centre (Gly351Ala) associated with progressive liver fibrosis
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS