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FLASH GENE
Symbol KRT10 contributors: mct/npt - updated : 11/09/2008
HGNC name keratin 10
HGNC id 6413
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved a central rod domain, with four helical domains (1A, 1B, 2A, 2B)
  • non alpha helical linkers (L1, 2, 3)
  • homology domain H1
  • variable region (V1, V2) and end sequences (E1, E2)
    • mono polymer heteromer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • intermediate filament family
  • type I keratin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    basic FUNCTION
  • heteropolymeric structural proteins which form the intermediate filament
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT1, KRT9
  • heterotetramer of two type I and two type II keratins, keratin 10 is generally associated with keratin I
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EHK2 , CIEHK
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS