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FLASH GENE

Symbol

KRT10

contributors: mct/npt - updated : 11/09/2008

HGNC name	keratin 10
HGNC id	6413

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed KRT10 8 - 2162 - 584 - Ivanova (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive esophagus       highly   liver       highly   pharynx       highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining epidermis stratum spinosum

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument cornified cell Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a conserved a central rod domain, with four helical domains (1A, 1B, 2A, 2B)
	non alpha helical linkers (L1, 2, 3)
	homology domain H1
	variable region (V1, V2) and end sequences (E1, E2)

mono polymer

heteromer , tetramer

HOMOLOGY

Homologene

FAMILY	intermediate filament family
	type I keratin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament

basic FUNCTION

heteropolymeric structural proteins which form the intermediate filament

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	dimerizing with KRT1, KRT9
	heterotetramer of two type I and two type II keratins, keratin 10 is generally associated with keratin I

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EHK2 , CIEHK

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS