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FLASH GENE
Symbol ITGA7 contributors: mct - updated : 21-03-2020
HGNC name integrin, alpha 7
HGNC id 6143
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminus of ITGA7 interacts with high temperature requirement A2 (HTRA2), a serine protease with a critical role in apoptosis
    • mono polymer heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY integrin family
    CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • sarcolemmal
  • type I membrane protein
  • colocalized with FHL2 and FHL3 at the periphery of Z-discs
    • basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • critical roles of ITGA7 and UTRN in maintaining myotendinous junction structure and enabling force transmission during muscle contraction
  • is an epigenetically regulated tumour suppressor gene
  • plays a key functional role in growth and invasiveness of glioblastoma stem-like cells (GSCs)
  • playing a role in mechanical stabilization of muscle cells
  • promotes cell proliferation, stemness but suppresses cell apoptosis in non-small-cell lung cancer (NSCLC)
  • role of ITGA7 and extracellular matrix interactions in Acute myeloid leukemia (AML) cell proliferation and extramedullary disease development
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • critical signaling mechanism of ITGA7, through the TIMP3/NFKB1/CCND1 pathway
    • a component dimerizing with ITGB1 in laminin receptor
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specific cellular receptor for the basement membrane protein laminin-1
  • ITGA7 increases the protease activity of HTRA2, and deletion of the HTRA2 interaction domain abrogates the cell death activity of ITGA7, whereas down-regulation of HTRA2 dramatically reduced cell death mediated by ITGA7
  • ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells
  • S100P interacts with ITGA7 and increases cancer cell migration and invasion in lung cancer
  • FOXC1 promotes colorectal cancer metastasis through transactivating ITGA7 and FGFR4 expression
    • cell & other
    REGULATION
    Other developmentally regulated during the formation of skeletal muscle cell
    ASSOCIATED DISORDERS
    corresponding disease(s) ITGA7D
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Acute myeloid leukemia (AML) with granulocytic sarcoma (GS)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • might serve as a potential biomarker for predicting increased AML risk and worse prognosis in AML patients
  • is a glioblastoma biomarker
  • prognostic factor in human Malignant pleural mesothelioma (MPM)
    • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    is a glioblastoma candidate therapeutic target (PMID: 28602620)
    cancerdigestiveoesophagus
    could be a potential therapeutic target in oesophageal squamous cell carcinoma treatment
    ANIMAL & CELL MODELS
  • alpha7 integrin null mices embryos exhibit vascular smooth muscle cell defects that result in cerebral vascular hemorrhaging