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FLASH GENE

Symbol

MLLT10

contributors: mct/ - updated : 08-09-2012

HGNC name	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
HGNC id	16063

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two PHD zinc finger (leukemia-associated-protein, LAP)
	C terminal basic leucine zipper domains

HOMOLOGY

interspecies

homolog to murine mllt10

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus

basic FUNCTION	truncated AF-10 has potentially cellular function in normal and malignant cells
	PICALM/MLLT10 might interfere with normal Ikaros (IKZF1)function, and thereby block lymphoid differentiation in PICALM/MLLT10 positive leukemias
	MLLT10/AF10 and DOT1L are essential activators to a large extent dedicated to Wnt target gene regulation
	participates in several chromosomal rearrangements that result in various leukemias (

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

DOT1L

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion       fused with MLL in acute lymphoblastic leukemia in translocation t(10;11)(p12;q23), and in acute megakaryoblastic leukemia tumoral fusion       with PICALM in T-ALL, AML, in translocation t(10;11) (p13;q14) tumoral fusion inversion     with CLP1 and MLL in monoblastic leukemia (Inv.Ins[10,11] [p12,q23-q12])

Susceptibility

to meningioma

Variant & Polymorphism SNP	rs11012732 influences meningioma risk

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS