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FLASH GENE
Symbol CCNE1 contributors: mct/npt - updated : 09-11-2018
HGNC name cyclin E1
HGNC id 1589
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in many tumors leading to a deregulated level of protein and kinase activity relative to the cell cycle and inducing chromosome instability
tumoral     --over  
significant factor of poor prognosis, especially in the node-positive groupof breast cancer (Potemski 2009)
tumoral     --over  
is associated with Stage 4 neuroblastomas and poor prognosis in patients
tumoral   amplification --over  
is amplified and overexpressed in osteosarcoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • highest positive predictive value for classical Hodgkin lymphoma (cHL)
  • Therapy target
    ANIMAL & CELL MODELS