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FLASH GENE

Symbol

EMR1

contributors: - updated : 23-03-2007

HGNC name	egf-like module containing, mucin-like, hormone receptor-like sequence 1
HGNC id	3336

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed Variant 1 - splicing 3150 Variant 1 97 886 - - Variant 2 - splicing 2966 Variant 2 - 821 - Bjarnadóttir sixty eight amino acids missing in the 7TM coding for a non-fonctional product Variant 3 - splicing 3056 Variant 3 - 867 - Bjarnadóttir missing fifty two amino acids between EGF-like domains 1 and 2 a stop codon and thirty three amino acids inserted in the 7TM domain coding for a non-fonctional product Variant 4 - splicing 635 Variant 4 - - - Bjarnadóttir missing the whole C-ter end one EGF-like domain a frame shift after the EGF-like domain 1 coding for a non-fonctional product

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five EGF-like domains
	a seven-span transmembrane segment (7tm_2)
	a G-protein-coupled receptor proteolytic site domain (GPS)

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to dog EMR1 (74.79 pc)

Homologene

FAMILY	G-protein coupled receptor superfamily
	LN-TM7 subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	coupling with Gs alpha protein
	activating adenylate cyclase
	could be involved in cell-cell interactions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal , signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS