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FLASH GENE
Symbol C4BPB contributors: mct - updated : 24-12-2013
HGNC name complement component 4 binding protein, beta
HGNC id 1328
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight short consensus repeats, sushi structure (see F13B, SRCP1)
  • several complement control protein domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • regulator of C3 convertase of classical pathway
  • having a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with C4BPA
  • complexing with protein S (role of the C4BP/protein S complex in regulation of complement on the surface of apoptotic cells)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C4, alpha chain
  • binds as a cofactor to C3B/C4B inactivator (C3bina), which then hydrolyzes the complement fragment C4B
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • PRELP interact with the complement inhibitor C4B-binding protein, C4BPB, and C4BPA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS