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FLASH GENE
Symbol C4BPB contributors: mct - updated : 24-12-2013
HGNC name complement component 4 binding protein, beta
HGNC id 1328
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight short consensus repeats, sushi structure (see F13B, SRCP1)
  • several complement control protein domain
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • regulator of C3 convertase of classical pathway
  • having a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with C4BPA
  • complexing with protein S (role of the C4BP/protein S complex in regulation of complement on the surface of apoptotic cells)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C4, alpha chain
  • binds as a cofactor to C3B/C4B inactivator (C3bina), which then hydrolyzes the complement fragment C4B
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • PRELP interact with the complement inhibitor C4B-binding protein, C4BPB, and C4BPA
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS