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FLASH GENE

Symbol

C4BPB

contributors: mct - updated : 24-12-2013

HGNC name	complement component 4 binding protein, beta
HGNC id	1328

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q32.1      Physical location : 207.262.211 - 207.273.335
Synonym symbol(s)	C4BP

DNA

TYPE	functioning gene
STRUCTURE	11.13 kb     7 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

text structure

see RCA@

MAPPING

cloned

Y

linked

status

confirmed

Map

see RCA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000716 6 - 1131 NP_000707 - 252 - 1995 7561113 V1 or A19 NM_001017364 6 - 1128 NP_001017364 - 251 - 1995 7561113 NM_001017365 7 - 968 NP_001017365 - 252 - 1995 7561113 V3 or A12 NM_001017366 7 - 965 NP_001017366 - 251 - 1995 7561113 NM_001017367 6 - 967 NP_001017367 - 252 - 1995 7561113

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Reproductive female system uterus cervix

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight short consensus repeats, sushi structure (see F13B, SRCP1)
	several complement control protein domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

immunity/defense

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	regulator of C3 convertase of classical pathway
	having a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	complexing with C4BPA
	complexing with protein S (role of the C4BP/protein S complex in regulation of complement on the surface of apoptotic cells)

INTERACTION

DNA

RNA

small molecule

protein	C4, alpha chain
	binds as a cofactor to C3B/C4B inactivator (C3bina), which then hydrolyzes the complement fragment C4B
	dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
	PRELP interact with the complement inhibitor C4B-binding protein, C4BPB, and C4BPA

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS