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FLASH GENE
Symbol C4BPB contributors: mct - updated : 24-12-2013
HGNC name complement component 4 binding protein, beta
HGNC id 1328
Location 1q32.1      Physical location : 207.262.211 - 207.273.335
Synonym symbol(s) C4BP
DNA
TYPE functioning gene
STRUCTURE 11.13 kb     7 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
text structure see RCA@
MAPPING cloned Y linked   status confirmed
Map see RCA@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1131 - 252 - 1995 7561113
V1 or A19
6 - 1128 - 251 - 1995 7561113
7 - 968 - 252 - 1995 7561113
V3 or A12
7 - 965 - 251 - 1995 7561113
6 - 967 - 252 - 1995 7561113
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight short consensus repeats, sushi structure (see F13B, SRCP1)
  • several complement control protein domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • regulator of C3 convertase of classical pathway
  • having a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with C4BPA
  • complexing with protein S (role of the C4BP/protein S complex in regulation of complement on the surface of apoptotic cells)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C4, alpha chain
  • binds as a cofactor to C3B/C4B inactivator (C3bina), which then hydrolyzes the complement fragment C4B
  • dependence on vitamin K-dependent PROS1 for eukaryotic cell secretion of C4BPB
  • PRELP interact with the complement inhibitor C4B-binding protein, C4BPB, and C4BPA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS