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FLASH GENE
Symbol HSD17B2 contributors: npt/ - updated : 14-01-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 2
HGNC id 5211
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Reproductivefemale systemplacenta  highly
 female systemovary  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short chain alcohol dehydrogenase
    • HOMOLOGY
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (sdr) family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • 17-beta-hydroxysteroid dehydrogenase, type II, NAD dependent
  • catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone
  • playing an essential role in the formation of active intracellular sex steroids
  • may be involved in the biological inactivation of these sex steroids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS