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FLASH GENE

Symbol

HSD17B2

contributors: npt/ - updated : 14-01-2006

HGNC name	hydroxysteroid (17-beta) dehydrogenase 2
HGNC id	5211

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant B - - 1000 isoform b - 291 - Labrie (1995) unknown function variant A 5 - 1450 isoform a - 387 - Labrie (1995)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Reproductive female system placenta     highly   female system ovary     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

short chain alcohol dehydrogenase

HOMOLOGY

Homologene

FAMILY

short-chain dehydrogenases/reductases (sdr) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,microsome

basic FUNCTION	17-beta-hydroxysteroid dehydrogenase, type II, NAD dependent
	catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone
	playing an essential role in the formation of active intracellular sex steroids
	may be involved in the biological inactivation of these sex steroids

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS