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FLASH GENE
Symbol ACADSB contributors: mct - updated : 18-11-2010
HGNC name acyl-Coenzyme A dehydrogenase, short/branched chain
HGNC id 91
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an all-alpha all terminal domain, transmembrane segment
  • C terminal domain
  • all-alpha, four helical up-and-down bundle
    • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY
  • acyl-CoA dehydrogenase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzing the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids
  • catalyzes the first matrix step in the mitochondrial beta-oxidation cycle with optimal activity toward butyryl- and hexanoyl-CoA
  • may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    mitochondrial fatty acid beta-oxidation system, first step
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
    FAD+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ACADSBD
    related resource MITOP database
    Susceptibility to hypertension
    Variant & Polymorphism other
  • possible involvement of genetic polymorphisms in ACADSB in essential hypertension
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS