Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SREBF1

contributors: mct - updated : 02-09-2020

HGNC name	sterol regulatory element binding transcription factor 1
HGNC id	11289

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IFAP2

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function significantly activated spinal cord tissue of both familial or sporadic ALS individuals, and this activation requires degradation of ER membrane resident protein INSIG1

Susceptibility

to obesity and type 2 diabetes in early-onset ALS or female patients

Variant & Polymorphism other	polymorphisms are associated with obesity and type 2 diabetes
	rs11868035 is likely to be associated with ALS in early-onset or female patients

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed digestive liver cirrhosis modulation of SREBF1 activity by SIK proteins would provide an attractive means for the regulation of nonalcoholic fatty liver diabete metabolic syndrom   reducing acetylation of SREBPF1 by targeting SIRT1 may be useful for treating metabolic disorders, including fatty liver, obesity, and type II diabetes neurology neurodegenerative   suppressing SREBP1 activation may have a therapeutic value in Amyotrophic lateral sclerosis

ANIMAL & CELL MODELS

Srebf1 acetylation levels were highly elevated in diet-induced obese mice