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FLASH GENE
Symbol S100A7 contributors: mct - updated : 19-02-2018
HGNC name S100 calcium binding protein A7
HGNC id 10497
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in the skin lesions of psoriasis, precancerous skin lesions, squamous cell carcinoma, basal cell carcinoma
tumoral     --over  
in breast cancer with poor prognosis (lobular carcinoma had higher levels compared with ductal tumours)
tumoral     --over  
in oral squamous cell carcinomas, and bladder cancer
constitutional     --over  
by keratinocytes surrounding the wound and is released into the wound exudat
constitutional     --over  
in psoriatic skin
tumoral     --over  
in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • significant increase of salivary psoriasin was observed in Systemic sclerosis (SSc) patients with pulmonary involvement when compared with other healthy and pathological controls
  • potential role of S100A7 overexpression in identifying oral lesions (OLs) with dysplasia at high risk of cancer development
  • Therapy target
    ANIMAL & CELL MODELS