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FLASH GENE

Symbol

S100A7

contributors: mct - updated : 19-02-2018

HGNC name	S100 calcium binding protein A7
HGNC id	10497

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	2.92 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	pter - AMY@ - D1S73 - D1S11 - D1S189 - D1S252 - D1S13 - D1Z5 - cen - S100A7 - MUC1 - SPTA1 - FY - ATP1A2 - APOA2 APOA2 - qter
Authors	Börglum (95)
Text	see S100A@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002963 3 - 450 NP_002954 11 101 - 2017 28976190

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth           pharynx         Reproductive male system testis       Homo sapiens Respiratory respiratory tract larynx

cells

System Cell Pubmed Species Stage Rna symbol Reproductive spermatozoa Homo sapiens Skin/Tegument keratinocyte

cell lineage
cell lines
fluid/secretion	amniotic, sperm

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	one S100 specific Nter
	two calcium binding domains
	an EF-hand motif
	central region, including only amino acids 35-80, is sufficient for full antibacterial activity
	one zinc-binding motif, located at the C-terminus, involved in antibacterial activity
	two EF-hand domains per subunit and two transition-metal-binding His3Asp sites at the dimer interface

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

S100 calcium binding protein family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus
text	also secreted by a non-classical secretory pathway

basic FUNCTION	acting as a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes
	may be a marker of agressive behavior in invasive breast cancer
	might play a role in the progression of skin cancer
	may have consequential immunobiological effects during the fetal development
	playing a role in modulating the immune response which may be a factor in early breast tumor progression (Mandal 2007)
	enhances survival mechanisms in breast cells through an interaction with c-jun activation domain binding protein 1 (COPS5) (West 2009)
	may mediate some of inflammatory cytokines effects in breast cancer (West 2010)
	psoriasin is likely produced by the structures of the ocular surface and is part of the innate immune system at the ocular surface and tear film
	an antimicrobial role seems likely for psoriasin in sperm
	is a positive regulator of survival and invasion of prostate cancer cells
	estrogen-induced S100A7 expression mediated by KDM1A may downregulate breast cancer cell proliferation, implying a potential tumor suppressor-like function for S100A7
	psoriasin plays a role in the differentiation of luminal mammary epithelial cells
	S100A7 and koebnerisin (S100A14) are released by keratinocytes during physiological wound healing
	Psoriasin and koebnerisin show antifibrotic effects and may lead to novel preventive and therapeutic strategies for fibroproliferative diseases
	functional role for AGER/S100A7 signaling in linking inflammation to aggressive breast cancer development
	contributes likely to the dysregulated differentiation process in the psoriasis epidermis
	metal-chelating protein expressed by epithelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of epidermal diffentiation complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein	potential role of KDM1A in regulating S100A7 expression
	S100A7 is repressed by YAP1 via the Hippo pathway
	S100A7 induces mature IL1A expression in normal human epidermal keratinocytes, which is dependent on AGER/MAPK14 and calpain-1 as the inhibitors or knockdown of them completely decreased the expression of mature IL1A

cell & other

REGULATION

induced by

OSM and IL6 in breast cancer (West 2010)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the skin lesions of psoriasis, precancerous skin lesions, squamous cell carcinoma, basal cell carcinoma tumoral     --over   in breast cancer with poor prognosis (lobular carcinoma had higher levels compared with ductal tumours) tumoral     --over   in oral squamous cell carcinomas, and bladder cancer constitutional     --over   by keratinocytes surrounding the wound and is released into the wound exudat constitutional     --over   in psoriatic skin tumoral     --over   in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	significant increase of salivary psoriasin was observed in Systemic sclerosis (SSc) patients with pulmonary involvement when compared with other healthy and pathological controls
	potential role of S100A7 overexpression in identifying oral lesions (OLs) with dysplasia at high risk of cancer development
Therapy target

ANIMAL & CELL MODELS