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FLASH GENE

Symbol

DSC2

contributors: mct - updated : 18-04-2020

HGNC name	desmocollin 2
HGNC id	3036

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

ARVD10

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in oesophageal squamous cell carcinoma (ESCC), and is associated with enhanced tumour metastasis and poor prognosisv

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	DSC2 is a useful immunohistochemical marker for separation of UC with squamous differentiation from pure Urothelial carcinoma (UC)
	DSC2 expression level was an independent prognostic factor for esophageal squamous cell carcinoma
Therapy target

ANIMAL & CELL MODELS