Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MMP10 contributors: mct/npt - updated : 09-05-2012
HGNC name matrix metalloproteinase 10 (stromelysin 2)
HGNC id 7156
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine residue essential for latency and involved in autocatalytic activation,
  • a catalytic domain with the zinc-binding site (the cysteine switch)
  • a hinge region
  • a hemopexin-like C terminal domain
    • conjugated HemoP , MetalloP
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to murine Mmp10 (76.4pc)
    homolog to rattus Mmp10 (75.6pc)
    Homologene
    FAMILY
  • peptidase M10A family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted, extracellular matrix
    basic FUNCTION
  • regulator in matrix remodeling
  • matrix metalloproteinase
  • enzyme that degrades proteoglycans and fibronectin
  • can degrade gelatins of type I, III, IV, V, weakly collagens III, IV, V
  • activating procollagenase
  • play an important role in cell proliferation, migration, differentiation and angiogenesis, as well as vascular integrity
  • secreted metalloproteinase with functions in skeletal development, wound healing, and vascular remodeling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two Zn2+ ions per subunit
    • protein
  • binding TIMPs in a 1:1 stoechiometry
  • HEY2 is an important regulator of MMP10 expression /Hey2 represses MMP10 expression)
  • MMP10 interacting with tissue inhibitors of metalloproteinases TIMP1 and TIMP2
    • cell & other
    REGULATION
    activated by proteinases, plasmin and other MMPs
    induced by C-reactive protein (Montero 2006)
    inhibited by TFPI2
    Other down-regulated by HDAC7 (Chang 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant lymphoma
    tumoral     --over  
    in squamous cell carcinoma by UV-irradiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential oral cancer markers (Yen 2009)
  • invovled in Merkel cell carcinoma (Suomela 2009)
  • upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation (Orbe 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS