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FLASH GENE
Symbol MMP10 contributors: mct/npt - updated : 09-05-2012
HGNC name matrix metalloproteinase 10 (stromelysin 2)
HGNC id 7156
Location 11q22.2      Physical location : 102.641.233 - 102.651.359
Synonym name
  • stromelysin 2
  • transin 2
  • matrix metalloprotease 10
    • Synonym symbol(s) STMY2, SL-2
    EC.number 3.4.24.22
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text member of the MMP cluster
    STRUCTURE 10.11 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site
    text structure
  • E-box sequences in MMP10 promoter play potentially an important role in the regulation of MMP10 expression by HEY2
    • MAPPING cloned Y linked N status confirmed
    Map see DRD2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1743 - 476 - Muller 1988
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Reproductivefemale systemovary   
    Respiratoryrespiratory tractlarynx   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text developing bone
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cysteine residue essential for latency and involved in autocatalytic activation,
  • a catalytic domain with the zinc-binding site (the cysteine switch)
  • a hinge region
  • a hemopexin-like C terminal domain
    • conjugated HemoP , MetalloP
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to murine Mmp10 (76.4pc)
    homolog to rattus Mmp10 (75.6pc)
    Homologene
    FAMILY
  • peptidase M10A family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text secreted, extracellular matrix
    basic FUNCTION
  • regulator in matrix remodeling
  • matrix metalloproteinase
  • enzyme that degrades proteoglycans and fibronectin
  • can degrade gelatins of type I, III, IV, V, weakly collagens III, IV, V
  • activating procollagenase
  • play an important role in cell proliferation, migration, differentiation and angiogenesis, as well as vascular integrity
  • secreted metalloproteinase with functions in skeletal development, wound healing, and vascular remodeling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • binding two Zn2+ ions per subunit
    • protein
  • binding TIMPs in a 1:1 stoechiometry
  • HEY2 is an important regulator of MMP10 expression /Hey2 represses MMP10 expression)
  • MMP10 interacting with tissue inhibitors of metalloproteinases TIMP1 and TIMP2
    • cell & other
    REGULATION
    activated by proteinases, plasmin and other MMPs
    induced by C-reactive protein (Montero 2006)
    inhibited by TFPI2
    Other down-regulated by HDAC7 (Chang 2006)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant lymphoma
    tumoral     --over  
    in squamous cell carcinoma by UV-irradiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • potential oral cancer markers (Yen 2009)
  • invovled in Merkel cell carcinoma (Suomela 2009)
  • upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation (Orbe 2009)
    • Marker
    Therapy target
    ANIMAL & CELL MODELS