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FLASH GENE

Symbol

PLCG2

contributors: mct/npt/pgu - updated : 24-05-2018

HGNC name	phospholipase C, gamma 2 (phosphatidylinositol-specific)
HGNC id	9066

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002661 33 - 4263 NP_002652 - 1265 - 2008 18728011

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Urinary kidney       moderately

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two SH2 domains
	one SH3
	two pleckstrin homology (PH) domains (pleckstrin homology (PH) domain, designated as the split PH domain (spPH), is both necessary and sufficient to effect activation of PLCG2 by Rac2)

HOMOLOGY

Homologene

FAMILY

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm

basic FUNCTION	phospholipase C, gamma 2, phosphatidylinositol specific
	catalyzing the hydrolysis of phosphatidylinositol 4,5 biphosphate to generate diacylglycerol and inositol 1,4,5 triphosphate
	mediating a wide variety of cellular stimuli
	couple immune recognition receptors to important calcium- and protein kinase C-dependent cellular functions
	responsible for ligand-mediated signaling in cells of the hematopoietic system, and playing a key role in the regulation of immune responses
	critical regulatory role in various immune and inflammatory pathways

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	substrate for parkin (PARK2 deficiency disrupts calcium homeostasis by modulating phospholipase C2 signalling)
	directly binds to RAC2 (activated by Rac2)
	TNFRSF11A-FAM102A signaling complex is necessary for PLCG2 phosphorylation that is required for the induction of NFATC1
	molecular switch PLCG2 interacts with BANK1 and that the interaction is promoted by B-cell receptor (BCR) stimulation
	kinase activity of BLK enhanced BANK1- PLCG2 binding and the interaction was suppressed upon BLK depletion
	BCNP1 promotes BCR signaling by modulating the phosphorylation of BLNK, SYK, and PLCG2

cell & other

REGULATION

activated by

markedly activated in intact cells by constitutively active Rac1(G12V), Rac2(G12V), and Rac3(G12V) but not by Cdc42(G12V) and RhoA(G14V)

ASSOCIATED DISORDERS

corresponding disease(s)

PLAID

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Plcg2-null mice exhibit increased perinatal lethality with gastrointestinal hemorrhages