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FLASH GENE

Symbol

CRHR1

contributors: mct/shn/pgu - updated : 16-09-2010

HGNC name	corticotropin releasing hormone receptor 1
HGNC id	2357

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

DEL17Q21 , DUP17Q21

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       gain of function promotes insulin secretion, thus contributing to the restoration of normoglycemic equilibrium constitutional     --over   in ectopic rather than eutopic endometrium of women with endometriosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	the medulla and the adrenal gland of mice lacking Crhr1 is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced
	mice null for the CRFR1 gene display markedly reduced anxiety and fail to exhibit the characteristic hormonal response to stress
	CRFR1-null mice have lower totalpancreatic islet numbers, consistent with a role for Crhr1 in the regulation of beta cell mass (Huising 2010)
	constitutive Crhr1 knockout (KO, Crhr1KO) mice show reduced anxiety-related behavior